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Extensive accumulation of diazepam and its major metabolite, desmethyldiazepam, has been noted following diazepam vs ativan • asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), chronic administration of diazepam in healthy elderly male subjects .
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Because elderly patients valium are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function .
Hepatic Insufficiency Decreases in clearance and protein valium tablet in urdu valium diazepam 5 mg efectos diazepam 5 mg tablet mylan valium tablets types binding, and increases in volume of distribution and half-life have been reported in patients with cirrhosis .
In such patients, a 2- to 5- fold increase in mean valium half-life has been reported .
Delayed elimination has also been reported for the active valium metabolite desmethyldiazepam .
Benzodiazepines valium are commonly implicated in hepatic Reference ID: 4029651 encephalopathy .
Increases in half-life have also been reported in hepatic fibrosis and in both acute and chronic hepatitis (see CLINICAL PHARMACOLOGY: Pharmacokinetics in valium Special Populations: Hepatic ADVERSE REACTIONS Side effects most commonly reported were drowsiness, fatigue, muscle weakness, and ataxia .

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